目录
摘要 Ⅲ
关键词 Ⅲ
Abstract Ⅳ
引言
1.引言 1
1.1课题背景及研究意义 1
1.2理论准备 1
1.3国内外研究现状 4
2.材料与方法 5
2.1材料 5
2.2方法 6
3.结果与分析 6
3.1单因素分析 6
3.1.1身体质量指数 7
3.1.2性别 8
3.1.3年龄 9
3.1.4吸烟与否 9
3.1.5是否手术 10
3.1.6是否化疗 11
3.1.7肿瘤分期 11
3.2cox多因素分析 12
4.讨论 13
5.结论 15
致谢 15
参考文献 15
基于生存分析对原发性肝癌预后影响因素的研究
摘要
本文探讨经治疗后肝癌患者远期生存及预后影响相关因素，确定相关预后影响因素，明确哪些是保护因素，哪些是危险因素，从而为获得较好的临床治疗选择。本文采用的研究方法是，首先对有可能影响肝癌预后的变量进行单因素分析并绘制生存曲线，p值小于0.05是有统计学差异。通过单因素分析筛选出的影响因素在进一步纳入Cox风险比例模型中并进行多因素分析，主要目的是找出影响原发性肝癌患者预后的独立因子。结果是通过单因素分析（H0为各因素对原发性肝癌患者预后无明显差异），可以得到患者的BMI指数、臀围、是否做过手术、是否化疗、是否进行过靶向治疗和肿瘤分期对原发性肝癌患者预后有比较显著的影响（p值小于0.05），而患者的年龄、性别、吸烟与否对肝癌患者的预后影响不大。结论是原发性肝癌患者的预后不仅受到治疗方式的影响，也受到患者的一般特征，如身体质量指数、病理特征等多因素的影响。身体质量指数、是否手术、是否化疗和肿瘤分期影响肝癌患者预后的独立因素。肝癌患者进行手术治疗和化疗，可以延长生存时间。
A STUDY ON THE FACTORS INFLUENCING THE PROGNOSIS OF PRIMARY LIVER CANCER BA *51今日免费论文网|www.51jrft.com +Q: ￥351916072$ 
SED ON SURVIVAL ANALYSIS
ABSTRACT
To explore the longterm survival and prognostic factors of HCC patients after treatment, determine the prognostic factors, and determine which are protective factors and which are risk factors, so as to obtain better clinical treatment options. Methods: the kaplanmeier method was used to calculate the survival curve. Univariate analysis was performed for all variables to be examined. There was a statistical difference when the p value was less than 0.05, and survival curves for each factor were plotted. Cox regression analysis was further used to find out the important factors affecting the prognosis of patients with primary liver cancer. Results: through the single factor analysis (H0 is no difference between the various factors on the prognosis of patients with primary liver cancer), can get the patients BMI, hip circumference, whether surgery, chemotherapy, whether for a targeted therapy and tumor stage has a significant effect on the prognosis of patients with primary liver cancer (p value is less than 0.05), and the patients age, gender, smoking or not has a little influence on the prognosis of patients with liver cancer. Conclusion: the prognosis of patients with primary liver cancer is not only influenced by the way of treatment, but also by the general characteristics of the patients, such as body mass index, pathological characteristics and other factors. Body mass index, surgery, chemotherapy, and tumor stage were independent factors affecting the prognosis of patients with lung adenocarcinoma. Surgical treatment and chemotherapy can prolong the survival time of patients with liver cancer.

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