目录
摘要 II
关键词 II
Abstract III
引言
引言 1
1　金属基纳米颗粒产生细胞毒性的机制 1
2　天然有机质影响金属基纳米颗粒细胞毒性的主要机制 2
2.1　活性氧 2
2.2　金属基纳米颗粒 3
2.2.1　天然有机质改变金属基纳米颗粒的zeta电位 3
2.2.2 天然有机质分散或团聚金属基纳米颗粒 4
2.2.3 天然有机质影响金属基纳米颗粒吸收内化 4
2.3　金属离子 5
2.3.1 天然有机质促进金属离子溶出 5
2.3.2 天然有机质抑制金属离子溶出 6
3　总结与展望 6
致谢 8
参考文献 9
天然有机质对金属基纳米颗粒细胞毒性的影响及其机制
摘 要
随着纳米技术的发展，大量金属基纳米颗粒（Metalbased Nanoparticles，MNPs）进入环境中，引发了人们对其细胞毒性以及毒性影响因素的高度关注。目前MNPs产生细胞毒性的机制已被广泛研究，而其中的多数研究都强调广泛分布于环境中的天然有机质（Natural Organic Matter，NOM）在影响MNPs细胞毒性的因素中占有重要地位。因此本文综述了MNPs毒害细胞的机制以及NOM对MNPs细胞毒性的影响机制。并认为MNPs对细胞产生的毒性是形成的活性氧（Reactive Oxygen Species，ROS）、颗粒态MNPs及其释放的金属离子共同作用的结果。继而从NOM减轻或加剧以上三个因素造成的细胞毒性这个角度来阐述NOM影响MNPs细胞毒性的机制。但是目前无论是MNPs产生细胞毒性的机制，还是NOM影响MNPs细胞毒性的机制都未被研究得十分透彻，同时MNPs的种类、粒径以及表面修饰，NOM的作用方式，受试细胞的选取等因素都会引起上述两个机制的改变，因此该研究方向还有许多值得挖掘和探索的地方。
EFFECT OF NATURAL ORGANIC MATTER ON CYTOTOXICITY OF METALBASED NANOPARTICL *51今日免费论文网|www.51jrft.com +Q: *351916072* 
ES AND ITS MECHANISM
ABSTRACT
With the development of nanotechnology, a large number of metalbased nanoparticles (MNPs) have entered the environment, causing people to pay close attention to their cytotoxicity and factors affecting toxicity. At present, the mechanism of MNPs producing cytotoxicity has been extensively studied, and most of them emphasize that natural organic matter (NOM) widely distributed in the environment is an important factor affecting MNPs cytotoxicity. Therefore, the mechanism of MNPs poisoning cells and the mechanism of NOM affecting the cytotoxicity of MNPs are summarized respectively in this review. Moreover, the toxicity of MNPs to cells is believed to be the result of the combined action of Reactive Oxygen Species (ROS), particulate MNPs and metal ions released by them. Then the writer elaborates the mechanism of NOM affecting MNPs cytotoxicity from the perspective that NOM alleviates or intensifies the cytotoxicity caused by the above three factors. However, neither the mechanism of MNPs producing cytotoxicity nor the mechanism of NOM affecting the cytotoxicity of MNPs has been thoroughly studied now. At the same time, the type, particle size and surface modification of MNPs, the mode of action of NOM, the selection of test cells and other factors will cause the above two mechanisms to change. Therefore, there are still many places worth exploring in this research direction.

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